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論文リスト

doi title author source_title year
2 10.1001/jama.2018.12440 Aging, Cell Senescence, And Chronic Disease Tchkonia, Tamara; Kirkland, James L. Jama 2018
1512 10.1002/anie.201901336 Jiang, Baishan; Wang, Eric S.; Donovan, Katherine A.; Liang, Yanke; Fischer, Eric S.; Zhang, Tinghu; Gray, Nathanael S., 0000-0001-5354-7403 Angewandte Chemie International Edition 2019
1758 10.1002/anie.201914396 Testa, Andrea, 0000-0002-8973-9711; Hughes, Scott J., 0000-0001-8360-929X; Lucas, Xavier, 0000-0003-0887-3976; Wright, Jane E.; Ciulli, Alessio, 0000-0002-8654-1670 Angewandte Chemie International Edition 2019
2402 10.1007/s00125-019-4934-x Cellular Senescence: At The Nexus Between Ageing And Diabetes Palmer, Allyson K.; Gustafson, Birgit; Kirkland, James L.; Smith, Ulf Diabetologia 2019
3419 10.1016/j.apsb.2019.08.001 Degradation Of Proteins By Protacs And Other Strategies Wang, Yang; Jiang, Xueyang; Feng, Feng; Liu, Wenyuan; Sun, Haopeng Acta Pharmaceutica Sinica B 2020
3742 10.1016/j.bmcl.2019.03.035 Selective Degradation Of Cdk6 By A Palbociclib Based Protac Rana, Sandeep; Bendjennat, Mourad; Kour, Smit; King, Hannah M.; Kizhake, Smitha; Zahid, Muhammad; Natarajan, Amarnath Bioorganic & Medicinal Chemistry Letters 2019
3743 10.1016/j.bmcl.2019.04.030 Edmondson, Scott D.; Yang, Bin; Fallan, Charlene Bioorganic & Medicinal Chemistry Letters 2019
3887 10.1016/j.cbpa.2019.02.022 Targeted Protein Degradation: Elements Of Protac Design Paiva, Stacey-Lynn; Crews, Craig M, 0000-0002-8456-2005 Current Opinion In Chemical Biology 2019
3911 10.1016/j.ccell.2019.10.002 A Potent And Selective Small-Molecule Degrader Of Stat3 Achieves Complete Tumor Regression In Vivo Bai, Longchuan; Zhou, Haibin; Xu, Renqi; Zhao, Yujun; Chinnaswamy, Krishnapriya; Mceachern, Donna; Chen, Jianyong; Yang, Chao-Yie; Liu, Zhaomin; Wang, Mi; Liu, Liu; Jiang, Hui; Wen, Bo; Kumar, Praveen; Meagher, Jennifer L.; Sun, Duxin; Stuckey, Jeanne A.; Wang, Shaomeng Cancer Cell 2019
4320 10.1016/j.cell.2019.10.005 Cellular Senescence: Defining A Path Forward Gorgoulis, Vassilis; Adams, Peter D.; Alimonti, Andrea; Bennett, Dorothy C.; Bischof, Oliver; Bishop, Cleo; Campisi, Judith; Collado, Manuel; Evangelou, Konstantinos; Ferbeyre, Gerardo; Gil, Jesus; Hara, Eiji; Krizhanovsky, Valery; Jurk, Diana; Maier, Andrea B.; Narita, Masashi; Niedernhofer, Laura; Passos, Joao F.; Robbins, Paul D.; Schmitt, Clemens A.; Sedivy, John; Vougas, Konstantinos; Von Zglinicki, Thomas; Zhou, Daohong; Serrano, Manuel; Demaria, Marco Cell 2019
4330 10.1016/j.cell.2019.11.031 Proteolysis-Targeting Chimeras As Therapeutics And Tools For Biological Discovery Burslem, George M.; Crews, Craig M. Cell 2020
4348 10.1016/j.cell.2020.03.008 Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities In Pancreas Cancer Ruscetti, Marcus; Morris, John P.; Mezzadra, Riccardo; Russell, James; Leibold, Josef; Romesser, Paul B.; Simon, Janelle; Kulick, Amanda; Ho, Yu-Jui; Fennell, Myles; Li, Jinyang; Norgard, Robert J.; Wilkinson, John E.; Alonso-Curbelo, Direna; Sridharan, Ramya; Heller, Daniel A.; De Stanchina, Elisa; Stanger, Ben Z.; Sherr, Charles J.; Lowe, Scott W. Cell 2020
4479 10.1016/j.celrep.2019.05.095 Small Extracellular Vesicles Are Key Regulators Of Non-Cell Autonomous Intercellular Communication In Senescence Via The Interferon Protein Ifitm3 Cell Reports 2019
4680 10.1016/j.chembiol.2018.11.006 Homolog-Selective Degradation As A Strategy To Probe The Function Of Cdk6 In Aml Brand, Matthias; Jiang, Baishan; Bauer, Sophie; Donovan, Katherine A.; Liang, Yanke; Wang, Eric S.; Nowak, Rados<U+0142>aw P.; Yuan, Jingting C.; Zhang, Tinghu; Kwiatkowski, Nicholas; Muller, Andre C.; Fischer, Eric S.; Gray, Nathanael S.; Winter, Georg E. Cell Chemical Biology 2019
4684 10.1016/j.chembiol.2019.11.004 Eed-Targeted Protacs Degrade Eed, Ezh2, And Suz12 In The Prc2 Complex Cell Chemical Biology 2020
4685 10.1016/j.chembiol.2019.11.006 Degradation Of Polycomb Repressive Complex 2 With An Eed-Targeted Bivalent Chemical Degrader Potjewyd, Frances; Turner, Anne-Marie W.; Beri, Joshua; Rectenwald, Justin M.; Norris-Drouin, Jacqueline L.; Cholensky, Stephanie H.; Margolis, David M.; Pearce, Kenneth H.; Herring, Laura E.; James, Lindsey I., 0000-0002-6034-7116 Cell Chemical Biology 2020
4686 10.1016/j.chembiol.2019.12.006 Exploring Targeted Degradation Strategy For Oncogenic Krasg12C Zeng, Mei; Xiong, Yuan; Safaee, Nozhat; Nowak, Rados<U+0142>aw P.; Donovan, Katherine A.; Yuan, Christine J.; Nabet, Behnam; Gero, Thomas W.; Feru, Frederic; Li, Lianbo; Gondi, Sudershan; Ombelets, Lincoln J.; Quan, Chunshan; Janne, Pasi A.; Kostic, Milka; Scott, David A.; Westover, Kenneth D.; Fischer, Eric S.; Gray, Nathanael S. Cell Chemical Biology 2020
4689 10.1016/j.chembiol.2020.07.020 Protacs: An Emerging Therapeutic Modality In Precision Medicine Nalawansha, Dhanusha A.; Crews, Craig M. Cell Chemical Biology 2020
4917 10.1016/j.cmet.2018.12.008 Obesity-Induced Cellular Senescence Drives Anxiety And Impairs Neurogenesis Ogrodnik, Mikolaj; Zhu, Yi; Langhi, Larissa G.P.; Tchkonia, Tamar; Kruger, Patrick; Fielder, Edward; Victorelli, Stella; Ruswhandi, Rifqha A.; Giorgadze, Nino; Pirtskhalava, Tamar; Podgorni, Oleg; Enikolopov, Grigori; Johnson, Kurt O.; Xu, Ming; Inman, Christine; Palmer, Allyson K.; Schafer, Marissa; Weigl, Moritz; Ikeno, Yuji; Burns, Terry C.; Passos, Joao F.; Von Zglinicki, Thomas; Kirkland, James L.; Jurk, Diana, 0000-0003-4486-0857 Cell Metabolism 2019
4918 10.1016/j.cmet.2019.01.021 Targeted Elimination Of Senescent Beta Cells Prevents Type 1 Diabetes Thompson, Peter J.; Shah, Ajit; Ntranos, Vasilis; Van Gool, Frederic; Atkinson, Mark; Bhushan, Anil Cell Metabolism 2019
4919 10.1016/j.cmet.2019.05.006 Aguayo-Mazzucato, Cristina; Andle, Joshua; Lee, Terrence B.; Midha, Ayush; Talemal, Lindsay; Chipashvili, Vaja; Hollister-Lock, Jennifer; Van Deursen, Jan; Weir, Gordon; Bonner-Weir, Susan Cell Metabolism 2019
5241 10.1016/j.csbj.2019.01.006 Bivalent Ligands For Protein Degradation In Drug Discovery Scheepstra, Marcel, 0000-0001-6735-6528; Hekking, Koen F.W.; Van Hijfte, Luc; Folmer, Rutger H.A. Computational And Structural Biotechnology Journal 2019
5256 10.1016/j.ctrv.2020.101974 Kras G12C Game Of Thrones, Which Direct Kras Inhibitor Will Claim The Iron Throne? Nagasaka, Misako, 0000-0001-5308-615X; Li, Yiwei; Sukari, Ammar, 0000-0003-1968-0459; Ou, Sai-Hong Ignatius; Al-Hallak, Mohammed Najeeb; Azmi, Asfar S., 0000-0003-1178-9505 Cancer Treatment Reviews 2020
5287 10.1016/j.ddtec.2018.12.002 Naito, Mikihiko; Ohoka, Nobumichi; Shibata, Norihito Drug Discovery Today: Technologies 2019
5288 10.1016/j.ddtec.2019.01.002 Pettersson, Mariell; Crews, Craig M., 0000-0002-8456-2005 Drug Discovery Today: Technologies 2019
5378 10.1016/j.ebiom.2018.09.005 Small-Molecule Protacs: An Emerging And Promising Approach For The Development Of Targeted Therapy Drugs An, Sainan; Fu, Liwu Ebiomedicine 2018
5379 10.1016/j.ebiom.2018.09.015 Fisetin Is A Senotherapeutic That Extends Health And Lifespan Yousefzadeh, Matthew J.; Zhu, Yi; Mcgowan, Sara J.; Angelini, Luise; Fuhrmann-Stroissnigg, Heike; Xu, Ming; Ling, Yuan Yuan; Melos, Kendra I.; Pirtskhalava, Tamar; Inman, Christina L.; Mcguckian, Collin; Wade, Erin A.; Kato, Jonathon I.; Grassi, Diego; Wentworth, Mark; Burd, Christin E.; Arriaga, Edgar A.; Ladiges, Warren L.; Tchkonia, Tamara; Kirkland, James L.; Robbins, Paul D.; Niedernhofer, Laura J. Ebiomedicine 2018
5380 10.1016/j.ebiom.2018.12.052 Senolytics In Idiopathic Pulmonary Fibrosis: Results From A First-In-Human, Open-Label, Pilot Study Justice, Jamie N.; Nambiar, Anoop M.; Tchkonia, Tamar; Lebrasseur, Nathan K.; Pascual, Rodolfo; Hashmi, Shahrukh K.; Prata, Larissa; Masternak, Michal M., 0000-0002-8483-930X; Kritchevsky, Stephen B.; Musi, Nicolas; Kirkland, James L. Ebiomedicine 2019
5383 10.1016/j.ebiom.2019.01.056 Senolytics And Senostatics As Adjuvant Tumour Therapy Short, Susan; Fielder, Edward; Miwa, Satomi; Von Zglinicki, Thomas Ebiomedicine 2019
5387 10.1016/j.ebiom.2019.08.069 Senolytics Decrease Senescent Cells In Humans: Preliminary Report From A Clinical Trial Of Dasatinib Plus Quercetin In Individuals With Diabetic Kidney Disease Hickson, Latonya J.; Langhi Prata, Larissa G.P.; Bobart, Shane A.; Evans, Tamara K.; Giorgadze, Nino; Hashmi, Shahrukh K.; Herrmann, Sandra M.; Jensen, Michael D.; Jia, Qingyi; Jordan, Kyra L.; Kellogg, Todd A.; Khosla, Sundeep; Koerber, Daniel M.; Lagnado, Anthony B.; Lawson, Donna K.; Lebrasseur, Nathan K.; Lerman, Lilach O.; Mcdonald, Kathleen M.; Mckenzie, Travis J.; Passos, Joao F.; Pignolo, Robert J.; Pirtskhalava, Tamar; Saadiq, Ishran M.; Schaefer, Kalli K.; Textor, Stephen C.; Victorelli, Stella G.; Volkman, Tammie L.; Xue, Ailing; Wentworth, Mark A.; Wissler Gerdes, Erin O.; Zhu, Yi; Tchkonia, Tamara; Kirkland, James L. Ebiomedicine 2019
8246 10.1016/j.molcel.2019.09.009 Autacs: Cargo-Specific Degraders Using Selective Autophagy Takahashi, Daiki; Moriyama, Jun; Nakamura, Tomoe; Miki, Erika; Takahashi, Eriko; Sato, Ayami; Akaike, Takaaki; Itto-Nakama, Kaori; Arimoto, Hirokazu Molecular Cell 2019
8259 10.1016/j.molcel.2020.01.010 Harnessing The Power Of Proteolysis For Targeted Protein Inactivation Verma, Rati; Mohl, Dane; Deshaies, Raymond J. Molecular Cell 2020
9569 10.1016/j.smim.2019.04.003 Senescent Cell Clearance By The Immune System: Emerging Therapeutic Opportunities Prata, Larissa G.P. Langhi; Ovsyannikova, Inna G.; Tchkonia, Tamara; Kirkland, James L. Seminars In Immunology 2018
9872 10.1016/j.trecan.2020.05.004 Senescent Cells In Cancer Therapy: Friends Or Foes? Wang, Boshi; Kohli, Jaskaren; Demaria, Marco Trends In Cancer 2020
11057 10.1021/acs.jmedchem.8b00506 Discovery Of Qca570 As An Exceptionally Potent And Efficacious Proteolysis Targeting Chimera (Protac) Degrader Of The Bromodomain And Extra-Terminal (Bet) Proteins Capable Of Inducing Complete And Durable Tumor Regression Qin, Chong; Hu, Yang; Zhou, Bing, 0000-0003-1813-8035; Fernandez-Salas, Ester; Yang, Chao-Yie; Liu, Liu; Mceachern, Donna; Przybranowski, Sally; Wang, Mi; Stuckey, Jeanne; Meagher, Jennifer; Bai, Longchuan; Chen, Zhuo; Lin, Mei; Yang, Jiuling; Ziazadeh, Danya N.; Xu, Fuming; Hu, Jiantao; Xiang, Weiguo; Huang, Liyue; Li, Siwei; Wen, Bo; Sun, Duxin; Wang, Shaomeng, 0000-0002-8782-6950 Journal Of Medicinal Chemistry 2018
11059 10.1021/acs.jmedchem.8b00909 Discovery Of Md-224 As A First-In-Class, Highly Potent, And Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable Of Achieving Complete And Durable Tumor Regression Li, Yangbing; Yang, Jiuling; Aguilar, Angelo; Mceachern, Donna; Przybranowski, Sally; Liu, Liu; Yang, Chao-Yie; Wang, Mi; Han, Xin; Wang, Shaomeng, 0000-0002-8782-6950 Journal Of Medicinal Chemistry 2018
11061 10.1021/acs.jmedchem.8b01413 Iterative Design And Optimization Of Initially Inactive Proteolysis Targeting Chimeras (Protacs) Identify Vz185 As A Potent, Fast, And Selective Von Hippel<U+2013>Lindau (Vhl) Based Dual Degrader Probe Of Brd9 And Brd7 Zoppi, Vittoria; Hughes, Scott J.; Maniaci, Chiara; Testa, Andrea, 0000-0002-8973-9711; Gmaschitz, Teresa; Wieshofer, Corinna; Koegl, Manfred; Riching, Kristin M.; Daniels, Danette L., 0000-0002-7659-3020; Spallarossa, Andrea; Ciulli, Alessio, 0000-0002-8654-1670 Journal Of Medicinal Chemistry 2018
11062 10.1021/acs.jmedchem.8b01572 Discovery Of Erd-308 As A Highly Potent Proteolysis Targeting Chimera (Protac) Degrader Of Estrogen Receptor (Er) Hu, Jiantao; Hu, Biao, 0000-0002-4691-6490; Wang, Mingliang; Xu, Fuming; Miao, Bukeyan; Yang, Chao-Yie; Wang, Mi; Liu, Zhaomin; Hayes, Daniel F.; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng, 0000-0002-8782-6950 Journal Of Medicinal Chemistry 2019
11063 10.1021/acs.jmedchem.8b01631 Discovery Of Ard-69 As A Highly Potent Proteolysis Targeting Chimera (Protac) Degrader Of Androgen Receptor (Ar) For The Treatment Of Prostate Cancer Han, Xin; Wang, Chao; Qin, Chong; Xiang, Weiguo; Fernandez-Salas, Ester; Yang, Chao-Yie; Wang, Mi; Zhao, Lijie; Xu, Tianfeng; Chinnaswamy, Krishnapriya; Delproposto, James; Stuckey, Jeanne; Wang, Shaomeng, 0000-0002-8782-6950 Journal Of Medicinal Chemistry 2019
11065 10.1021/acs.jmedchem.8b01826 Highly Selective Ptk2 Proteolysis Targeting Chimeras To Probe Focal Adhesion Kinase Scaffolding Functions Popow, Johannes; Arnhof, Heribert; Bader, Gerd; Berger, Helmut; Ciulli, Alessio, 0000-0002-8654-1670; Covini, David; Dank, Christian; Gmaschitz, Teresa; Greb, Peter; Karolyi-Ozguer, Jale; Koegl, Manfred; Mcconnell, Darryl B.; Pearson, Mark; Rieger, Maria; Rinnenthal, Joerg; Roessler, Vanessa; Schrenk, Andreas; Spina, Markus; Steurer, Steffen; Trainor, Nicole; Traxler, Elisabeth; Wieshofer, Corinna; Zoephel, Andreas; Ettmayer, Peter, 0000-0002-8422-2625 Journal Of Medicinal Chemistry 2019
11067 10.1021/acs.jmedchem.9b00516 Development Of Multifunctional Histone Deacetylase 6 Degraders With Potent Antimyeloma Activity Wu, Hao; Yang, Ka, 0000-0001-8937-7397; Zhang, Zhongrui; Leisten, Eric D.; Li, Ziyuan; Xie, Haibo; Liu, Jin; Smith, Kerry A.; Novakova, Zora, 0000-0001-9804-6346; Barinka, Cyril, 0000-0003-2751-3060; Tang, Weiping, 0000-0002-0039-3196 Journal Of Medicinal Chemistry 2019
11069 10.1021/acs.jmedchem.9b00871 Potent And Preferential Degradation Of Cdk6 Via Proteolysis Targeting Chimera Degraders Su, Shang, 0000-0003-0228-5380; Yang, Zimo; Gao, Hongying; Yang, Haiyan; Zhu, Songbiao; An, Zixuan; Wang, Juanjuan; Li, Qing; Chandarlapaty, Sarat; Deng, Haiteng; Wu, Wei; Rao, Yu, 0000-0002-4356-8531 Journal Of Medicinal Chemistry 2019
11071 10.1021/acs.jmedchem.9b01180 Discovery Of A Covalent Inhibitor Of Krasg12C (Amg 510) For The Treatment Of Solid Tumors Lanman, Brian A., 0000-0002-8768-7188; Allen, Jennifer R.; Allen, John G.; Amegadzie, Albert K.; Ashton, Kate S.; Booker, Shon K.; Chen, Jian Jeffrey; Chen, Ning; Frohn, Michael J.; Goodman, Guy; Kopecky, David J.; Liu, Longbin; Lopez, Patricia; Low, Jonathan D.; Ma, Vu; Minatti, Ana E.; Nguyen, Thomas T.; Nishimura, Nobuko; Pickrell, Alexander J.; Reed, Anthony B.; Shin, Youngsook, 0000-0003-3866-354X; Siegmund, Aaron C.; Tamayo, Nuria A.; Tegley, Christopher M.; Walton, Mary C.; Wang, Hui-Ling, 0000-0003-2748-5266; Wurz, Ryan P., 0000-0003-1413-5208; Xue, May; Yang, Kevin C.; Achanta, Pragathi; Bartberger, Michael D., 0000-0002-5167-3139; Canon, Jude; Hollis, L. Steven; Mccarter, John D.; Mohr, Christopher; Rex, Karen; Saiki, Anne Y.; San Miguel, Tisha; Volak, Laurie P.; Wang, Kevin H.; Whittington, Douglas A., 0000-0002-5946-8543; Zech, Stephan G.; Lipford, J. Russell; Cee, Victor J., 0000-0002-7714-397X Journal Of Medicinal Chemistry 2019
11072 10.1021/acs.jmedchem.9b01393 Discovery Of Highly Potent And Efficient Protac Degraders Of Androgen Receptor (Ar) By Employing Weak Binding Affinity Vhl E3 Ligase Ligands Han, Xin; Zhao, Lijie; Xiang, Weiguo; Qin, Chong; Miao, Bukeyan; Xu, Tianfeng; Wang, Mi; Yang, Chao-Yie; Chinnaswamy, Krishnapriya; Stuckey, Jeanne; Wang, Shaomeng, 0000-0002-8782-6950 Journal Of Medicinal Chemistry 2019
11073 10.1021/acs.jmedchem.9b01530 Structure-Based Discovery Of Sd-36 As A Potent, Selective, And Efficacious Protac Degrader Of Stat3 Protein Zhou, Haibin; Bai, Longchuan; Xu, Renqi; Zhao, Yujun, 0000-0003-1035-2272; Chen, Jianyong; Mceachern, Donna; Chinnaswamy, Krishnapriya; Wen, Bo; Dai, Lipeng; Kumar, Praveen; Yang, Chao-Yie, 0000-0002-5445-0109; Liu, Zhaomin; Wang, Mi; Liu, Liu; Meagher, Jennifer L.; Yi, Han; Sun, Duxin; Stuckey, Jeanne A.; Wang, Shaomeng, 0000-0002-8782-6950 Journal Of Medicinal Chemistry 2019
11076 10.1021/acs.jmedchem.9b02052 Identification Of The Clinical Development Candidate Mrtx849, A Covalent Krasg12C Inhibitor For The Treatment Of Cancer Fell, Jay B., 0000-0002-5770-1225; Fischer, John P.; Baer, Brian R.; Blake, James F.; Bouhana, Karyn; Briere, David M.; Brown, Karin D.; Burgess, Laurence E.; Burns, Aaron C.; Burkard, Michael R.; Chiang, Harrah; Chicarelli, Mark J.; Cook, Adam W.; Gaudino, John J.; Hallin, Jill; Hanson, Lauren; Hartley, Dylan P.; Hicken, Erik J.; Hingorani, Gary P.; Hinklin, Ronald J.; Mejia, Macedonio J.; Olson, Peter; Otten, Jennifer N.; Rhodes, Susan P.; Rodriguez, Martha E.; Savechenkov, Pavel; Smith, Darin J.; Sudhakar, Niranjan; Sullivan, Francis X.; Tang, Tony P.; Vigers, Guy P.; Wollenberg, Lance; Christensen, James G.; Marx, Matthew A., 0000-0003-2351-4787 Journal Of Medicinal Chemistry 2020
11592 10.1021/acscentsci.0c00411 Targeted Degradation Of Oncogenic Krasg12C By Vhl-Recruiting Protacs Bond, Michael J.; Chu, Ling; Nalawansha, Dhanusha A.; Li, Ke; Crews, Craig M., 0000-0002-8456-2005 Acs Central Science 2020
11613 10.1021/acscentsci.9b00713 Reversible Spatiotemporal Control Of Induced Protein Degradation By Bistable Photoprotacs Pfaff, Patrick, 0000-0002-9761-2497; Samarasinghe, Kusal T. G.; Crews, Craig M., 0000-0002-8456-2005; Carreira, Erick M., 0000-0003-1472-490X Acs Central Science 2019
11620 10.1021/acschembio.8b00692 Quantitative Live-Cell Kinetic Degradation And Mechanistic Profiling Of Protac Mode Of Action Riching, Kristin M.; Mahan, Sarah; Corona, Cesear R.; Mcdougall, Mark; Vasta, James D.; Robers, Matthew B.; Urh, Marjeta; Daniels, Danette L., 0000-0002-7659-3020 Acs Chemical Biology 2018
11621 10.1021/acschembio.8b01083 Covalent Ligand Screening Uncovers A Rnf4 E3 Ligase Recruiter For Targeted Protein Degradation Applications Ward, Carl C.; Kleinman, Jordan I.; Brittain, Scott M.; Lee, Patrick S., 0000-0002-0517-120X; Chung, Clive Yik Sham; Kim, Kenneth; Petri, Yana; Thomas, Jason R.; Tallarico, John A.; Mckenna, Jeffrey M.; Schirle, Markus, 0000-0003-4933-2623; Nomura, Daniel K., 0000-0003-1614-8360 Acs Chemical Biology 2019
11622 10.1021/acschembio.8b01094 Tinworth, Christopher P., 0000-0002-2756-707X; Lithgow, Hannah; Dittus, Lars; Bassi, Zuni I., 0000-0003-4309-9656; Hughes, Sophie E.; Muelbaier, Marcel, 0000-0002-5414-0258; Dai, Han; Smith, Ian E. D.; Kerr, William J., 0000-0002-1332-785X; Burley, Glenn A., 0000-0002-4896-113X; Bantscheff, Marcus, 0000-0002-8343-8977; Harling, John D. Acs Chemical Biology 2019
11623 10.1021/acschembio.9b00092 Spr-Measured Dissociation Kinetics Of Protac Ternary Complexes Influence Target Degradation Rate Roy, Michael J.; Winkler, Sandra; Hughes, Scott J.; Whitworth, Claire; Galant, Michael; Farnaby, William; Rumpel, Klaus; Ciulli, Alessio, 0000-0002-8654-1670 Acs Chemical Biology 2019
11782 10.1021/acsmedchemlett.9b00597 Protac Technology: Opportunities And Challenges Gao, Hongying, 0000-0001-5078-1317; Sun, Xiuyun, 0000-0001-9634-2707; Rao, Yu, 0000-0002-4356-8531 Acs Medicinal Chemistry Letters 2020
12134 10.1021/jacs.8b08008 Addressing Kinase-Independent Functions Of Fak Via Protac-Mediated Degradation Cromm, Philipp M., 0000-0001-5291-3379; Samarasinghe, Kusal T. G.; Hines, John; Crews, Craig M., 0000-0002-8456-2005 Journal Of The American Chemical Society 2018
12168 10.1021/jacs.8b10320 Enhancing Antiproliferative Activity And Selectivity Of A Flt-3 Inhibitor By Proteolysis Targeting Chimera Conversion Burslem, George M., 0000-0002-2812-983X; Song, Jayoung; Chen, Xin; Hines, John; Crews, Craig M., 0000-0002-8456-2005 Journal Of The American Chemical Society 2018
12287 10.1021/jacs.9b02822 Rapid Covalent-Probe Discovery By Electrophile-Fragment Screening Resnick, Efrat; Bradley, Anthony; Gan, Jinrui; Douangamath, Alice; Krojer, Tobias; Sethi, Ritika; Geurink, Paul P.; Aimon, Anthony; Amitai, Gabriel; Bellini, Dom; Bennett, James; Fairhead, Michael; Fedorov, Oleg; Gabizon, Ronen; Gan, Jin; Guo, Jingxu; Plotnikov, Alexander; Reznik, Nava; Ruda, Gian Filippo; Diaz-Saez, Laura; Straub, Verena M.; Szommer, Tamas; Velupillai, Srikannathasan; Zaidman, Daniel; Zhang, Yanling; Coker, Alun R.; Dowson, Christopher G.; Barr, Haim M.; Wang, Chu, 0000-0002-6925-1268; Huber, Kilian V.M., 0000-0002-1103-5300; Brennan, Paul E., 0000-0002-8950-7646; Ovaa, Huib, 0000-0002-0068-054X; Von Delft, Frank; London, Nir, 0000-0003-2687-0699 Journal Of The American Chemical Society 2019
12352 10.1021/jacs.9b06422 Light-Induced Protein Degradation With Photocaged Protacs Xue, Gang; Wang, Kun; Zhou, Danli; Zhong, Hanbing; Pan, Zhengying, 0000-0002-4312-7103 Journal Of The American Chemical Society 2019
12609 10.1038/s41375-019-0440-x Sun, Yonghui; Ding, Ning; Song, Yuqin; Yang, Zimo; Liu, Wanli; Zhu, Jun; Rao, Yu Leukemia 2019
12662 10.1038/s41392-019-0101-6 Protacs: Great Opportunities For Academia And Industry Sun, Xiuyun; Gao, Hongying; Yang, Yiqing; He, Ming; Wu, Yue; Song, Yugang; Tong, Yan; Rao, Yu Signal Transduction And Targeted Therapy 2019
12703 10.1038/s41421-018-0079-1 A Chemical Approach For Global Protein Knockdown From Mice To Non-Human Primates Sun, Xiuyun; Wang, Jun; Yao, Xia; Zheng, Wen; Mao, Yang; Lan, Tianlong; Wang, Liguo; Sun, Yonghui; Zhang, Xinyi; Zhao, Qiuye; Zhao, Jianguo; Xiao, Rui-Ping; Zhang, Xiuqin; Ji, Guangju; Rao, Yu Cell Discovery 2019
12727 10.1038/s41422-020-0314-9 Cai, Yusheng; Zhou, Huanhuan; Zhu, Yinhua; Sun, Qi; Ji, Yin; Xue, Anqi; Wang, Yuting; Chen, Wenhan; Yu, Xiaojie; Wang, Longteng; Chen, Han; Li, Cheng; Luo, Tuoping, 0000-0003-2156-3198; Deng, Hongkui Cell Research 2020
12883 10.1038/s41467-018-07825-3 Impaired Immune Surveillance Accelerates Accumulation Of Senescent Cells And Aging Ovadya, Yossi; Landsberger, Tomer; Leins, Hanna; Vadai, Ezra; Gal, Hilah; Biran, Anat; Yosef, Reut; Sagiv, Adi; Agrawal, Amit; Shapira, Alon; Windheim, Joseph; Tsoory, Michael; Schirmbeck, Reinhold; Amit, Ido, 0000-0002-5880-2845; Geiger, Hartmut; Krizhanovsky, Valery, 0000-0002-3977-5482 Nature Communications 2018
12895 10.1038/s41467-018-08027-7 Differential Protac Substrate Specificity Dictated By Orientation Of Recruited E3 Ligase Smith, Blake E.; Wang, Stephen L., 0000-0002-3519-5130; Jaime-Figueroa, Saul; Harbin, Alicia; Wang, Jing; Hamman, Brian D.; Crews, Craig M., 0000-0002-8456-2005 Nature Communications 2019
13068 10.1038/s41467-019-10335-5 Senescent Cells Evade Immune Clearance Via Hla-E-Mediated Nk And Cd8+ T Cell Inhibition Pereira, Branca I.; Devine, Oliver P.; Vukmanovic-Stejic, Milica; Chambers, Emma S., 0000-0003-0990-8835; Subramanian, Priya; Patel, Neil; Virasami, Alex, 0000-0003-1861-9357; Sebire, Neil J.; Kinsler, Veronica; Valdovinos, Alexis; Lesaux, Claude Jourdan; Passos, Joao F.; Antoniou, Antony; Rustin, Malcom H. A.; Campisi, Judith; Akbar, Arne N. Nature Communications 2019
13078 10.1038/s41467-019-10460-1 Exploiting Interconnected Synthetic Lethal Interactions Between Parp Inhibition And Cancer Cell Reversible Senescence Fleury, Hubert; Malaquin, Nicolas; Tu, Veronique, 0000-0002-1856-7350; Gilbert, Sophie; Martinez, Aurelie; Olivier, Marc-Alexandre, 0000-0002-7919-448X; Sauriol, Alexandre, 0000-0002-2690-7765; Communal, Laudine; Leclerc-Desaulniers, Kim; Carmona, Euridice; Provencher, Diane; Mes-Masson, Anne-Marie; Rodier, Francis Nature Communications 2019
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